TP53 and neoplasm: In addition, the tendency of wild-type and mutant p53 to form functional higher-order structures (HOS) (Ishimaru et al., 2003; Ano Bom et al., 2012; Silva et al., 2013; Ghosh et al., 2014; Silva et al., 2014; de Oliveira et al., 2015; Silva and Cordeiro, 2016; Ghosh et al., 2017; Pedrote et al., 2018; de Oliveira et al., 2019; de Oliveira et al., 2020; Lima et al., 2020; Pedrote et al., 2020; Navalkar et al., 2021; Petronilho et al., 2021) drives the tumor-suppressive vs. oncogenic responses (Figure 2B).