TP53 and neoplasm: The follow-up of cancer cells and tumor tissues carrying TP53 mutations raised novel functionalities to p53 and the title of a pleiotropic regulator with oncogenic activity (Eliyahu et al., 1984; Jenkins et al., 1984; Parada et al., 1984; Wolf et al., 1984; Eliyahu et al., 1985; Michalovitz et al., 1986; Malkin et al., 1990; Srivastava et al., 1990).