In the backstage of these canonical pro-survival programs, p53 works in non-canonical tumor-suppressive programs that include genome stability avoiding aneuploid cells, inhibiting glycolysis and gluconeogenesis, and promoting oxidative phosphorylation to protect cells from metabolic reprogramming (Green and Kroemer, 2009; Vousden and Ryan, 2009; Li et al., 2012; Valente et al., 2013; Kruiswijk et al., 2015) (Figure 3). The gene discussed is TP53; the disease is neoplasm.