Seminal articles highlight the presence of mutant p53 aggregates in tumor cells (Levy et al., 2011; Xu et al., 2011; Ano Bom et al., 2012; Yang-Hartwich et al., 2015; Pedrote et al., 2020), the cell-to-cell p53 transmissibility (Forget et al., 2013; Ghosh et al., 2017; Navalkar et al., 2021), and the recovery of the native phenotype by pharmacological inhibition of the p53 aggregation (Soragni et al., 2016; Ferraz da Costa et al., 2018; Silva et al., 2018; Miller et al., 2019; Rangel et al., 2019; Palanikumar et al., 2021). The gene discussed is TP53; the disease is neoplasm.