This negative regulator of inflammation and phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K) axis has also been studied for its role in balancing apoptosis and oncogenic transformation in normal epithelial cells and as a prognostic biomarker in breast cancer (Buscaglia and Li, 2011; Wang et al., 2015b; Ma et al., 2015; Fusco et al., 2020b; Amirfallah et al., 2021; Fusco et al., 2021; Sajjadi et al., 2021). This evidence concerns the gene PTEN and breast carcinoma.