Therefore, sex interacts with Asn synthesis and CRC through GPER activation; nutrient supply influences the function of estrogen and GPER1 in KRAS-mutant CRC by upregulating ASNS expression, Asn synthesis, PI3K/AKT and HIF-1α-mediated SOX12 overexpression (Figure 2). This evidence concerns the gene PIK3CA and colorectal carcinoma.