Selvakumar P et al. found that knockdown of the von Hippel-Lindau (VHL) tumor suppressor gene in renal cell carcinoma (RCC) cell lines would disturb the expression of Na+ and K+ transported proteins which is associated with RCC initiation and progression (Selvakumar et al., 2014). This evidence concerns the gene VHL and hereditary clear cell renal cell carcinoma.