Consistent with the above results, transcriptional results from TCGA and ICGC databases showed that DOCK3, KIF5A, LYPD6, PEX5L, SLC13A1, SLC6A19, and TFAP2A were dramatically down-regulated in ccRCC and RCC tumor samples than normal samples (Supplementary Figures S10A,B). This evidence concerns the gene LYPD6 and renal cell carcinoma.