Consistent with the above results, transcriptional results from TCGA and ICGC databases showed that DOCK3, KIF5A, LYPD6, PEX5L, SLC13A1, SLC6A19, and TFAP2A were dramatically down-regulated in ccRCC and RCC tumor samples than normal samples (Supplementary Figures S10A,B). The gene discussed is TFAP2A; the disease is nonpapillary renal cell carcinoma.