STING1 and neoplasm: As STING is expressed on most cells, the systemic administration of CDA also shows severe systemic toxicity, which makes the use of combined treatment with TCEs and CDA unacceptable.[25] Thus, we rationally designed PmTriTNE to exploit the intrinsically weak acidic TME to preferentially unmask and activate TriTNE in tumor tissues over healthy tissues, thereby mitigating off‐tumor toxicity.