IGHE and asthma: Its actions in asthma include switching plasma cell antibody synthesis from IgM to IgE production, promoting migration of eosinophils into the lung, increasing permeability and sloughing of airway epithelial cells, increasing mucus production, production of inducible nitric oxide synthase by airway epithelial cells, the transformation of airway fibroblasts into myofibroblasts, proliferation of airway smooth muscle, and stimulation of airway hyperresponsiveness, among others [4].