Likewise, our previous studies in mice showed that myocardial copper levels were reduced by 50% at 7 days after MI [25], whereas cardiac-specific knockout of Commd1 restored copper content in ischemic myocardium to 60% of normal levels, resulting in partial restoration of expression of HIF-1 target angiogenic genes such as Vegfa and Flt1 [26]. Here, COMMD1 is linked to myocardial infarction.