ACE2 and Cognitive impairment: For instance, elevated ACE2 activity in the brain induced by intraperitoneal administration of an established ACE2 activator (diminazene aceturate) reduces Aβ-related pathology and delays cognitive impairment in symptomatic (aged) Tg2576 mice and protects against the onset of cognitive decline in presymptomatic (younger) Tg2576 mice [93].