As shown in Fig. 11, B–D, intravenous injection of Hc-CATH at 2 h before ZIKV infection significantly decreased ZIKV replication in C57BL/6J mice (Fig. 11B), Ifnar1−/− mice (Fig. 11C), fetal placenta, and fetal mice (Fig. 11D), implying that intravenous injection of Hc-CATH at 2 h before ZIKV challenge provides prophylactic efficacy against ZIKV infection in mice. The gene discussed is IFNAR1; the disease is Zika virus infectious disease.