In recent years, a series of AMPs/host defensive peptides were shown to confer protection against ZIKV infection, including human cathelicidin AMP (46) and defensin AMP (47), bovine cathelicidin AMP (46), scorpion venom peptides derived from Scorpio maurus palmatus (48) and Euscorpiops validus (49), spider venom peptide from Alopecosa nagpag (50), frog host defense peptide from Indosylvirana aurantiaca (51), and snail antibacterial peptide from Pomacea poeyana (52). This evidence concerns the gene ADSL and Zika virus infectious disease.