Compared with BPH-1 or sh-RNA-BPH-1 groups, the expression of Bcl-2 in the sh-beclin1 BPH-1 cells was significantly reduced (both p < 0.001), while the expression of Bax was augmented (both p < 0.01) (Fig. 7). Here, BECN1 is linked to benign prostatic hyperplasia.