BECN1 and benign prostatic hyperplasia: The results showed that the apoptotic rate of the sh-beclin-1-BPH-1 group was significantly increased compared to the BPH-1 cell group or the Sh-RNA-BPH-1 group (both p < 0.01) (Fig. 5), suggesting that the signaling pathway-related apoptosis was activated after the Beclin-1 gene was silenced, which promoted apoptosis of the cells.