Compared with the BPH-1 or sh-RNA-BPH-1 group, the expression of PARP-1 in the sh-Beclin1-BPH-1 group was significantly decreased (both p < 0.001), while the 89 kd fragmentation of PARP-1 was obviously increased (Fig. 6). The gene discussed is PARP1; the disease is benign prostatic hyperplasia.