RB1 and cancer: Two of the individual CTCs (CTC1 and CTC2, Fig. 2c) and the CTC pool had homogenous copy-number profiles, and included amplification on 1q and 8q (MYC), 11q (CCND1, FGF3, FGF4) and allelic loss of regions including several cancer genes on 3p (BAP1), 13q(RB1, BRCA2) and 17p (MAP2K4).