The present results suggested that compared with the control group, the result of real-time PCR revealed the mRNA expression level of ATF6 and XBP1 both were increased in the sepsis group (both P < 0.0001) and dramatically decreased in the treatment group (P = 0.0003, P < 0.0001, respectively) (Fig. 4A, B). Here, ATF6 is linked to Sepsis.