Incubation of CL40 colon cancer cells with IMC-KRASG12D together with HLA-A*11+ PBMC resulted in IMC-KRASG12D concentration dependent IFNγ, IL-2 and Granzyme B release as well as redirected T cell killing in a time- and dose-dependent manner with a mean EC50 value of 28.5 ± 25 pM (Fig. 5e, f and supplementary Fig S9). Here, GZMB is linked to malignant colon neoplasm.