When the study population was divided into MLH1 and MSH2 PV carriers, no difference in the age of disease diagnosis was observed for the MSH2 PV carriers whereas for the MLH1 PV carriers both the rs3802842 and rs16892766 polymorphisms were shown to be associated with a significant difference in the age of colorectal cancer diagnosis. This evidence concerns the gene MLH1 and colorectal cancer.