Although LRRK2-associated PD cases may not show characteristic αSyn pathology such as Lewy bodies or neurites on autopsy, the current GNE-7915 regimen effectively inhibited LRRK2 kinase hyperactivity, which can potentially attenuate pathogenic events caused by aberrant LRRK2 hyperactivity, such as endo-lysosomal dysfunction58. This evidence concerns the gene LRRK2 and Parkinson disease.