In another European multicentre study including more than 3000 patients with acute cough, the addition of C-reactive protein > 30 mg/l to clinical signs of pneumonia (absence of runny nose and presence of breathlessness, crackles and diminished breath sounds on auscultation, tachycardia, and fever) improved the diagnostic classification [52]. The gene discussed is CRP; the disease is susceptibility to pneumonia measurement.