SIRT1 and myocardial infarction: 2019). SIRT1 was indeed activated by SUMOylation to stabilize its protein levels (Han et al. 2016). The SUMOylation of SIRT1 is involved in inhibition of cellular senescence and acted as a cardioprotective factor against MI/R injury (Yang et al. 2007; Han et al. 2016; Chen et al. 2019).