CRP is the most common acute-phase protein that can be elevated in the early stages of RA and can promote the proliferation of synovial fibroblasts in the joints of RA patients.[15]CRP can activate the RANKL system and directly induce osteoclast activation aggravating bone destruction.[16] Platelets are involved in the coagulation process and in the immune and inflammatory responses that can amplify joint inflammation in RA.[17] Although most patients with RA have elevated ESR, CPR, and PLT levels during the active phase, these changes do not occur in all patients. This evidence concerns the gene CRP and rheumatoid arthritis.