ACE and diabetes mellitus: However, in a network meta-analysis comparing the association between antihypertensive drugs and incident DM, ARB or angiotensin-converting enzyme (ACE) inhibitor had the lowest risk and followed by CCB and placebo, beta-blockers, and diuretics in rank order.[27] Compared to placebo, CCB has a lower risk of diabetes, so the detrimental effect of CCB seems to be less likely.[27]