Statin induces the accumulation of fatty acids, which causes a detrimental effect on insulin signaling in muscle cells.[20] Consistent with these results, HOMA-IR showed a significant dose-dependent increase with 10, 20, and 40 mg of rosuvastatin in hyperlipidemia patients with IFG.[21] Studies have shown that patients with several pre-existing risk factors for diabetes are at a higher risk of developing diabetes due to statins.[3,6] In this context, patients at risk of cardiovascular disease could also possibly have a higher risk of developing diabetes due to statins. This evidence concerns the gene INS and diabetes mellitus.