In order to analyze whether the 14 differentially expressed miRNAs were related to the occurrence of lung cancer, we selected mRNAs related to Wnt signaling pathway, PI3K-Akt signaling pathway, and Notch signaling pathway from the target mRNA predicted by miRNA to explore the interactions between miRNA and these 3 signaling pathways. The gene discussed is PIK3CB; the disease is lung cancer.