The correlation between hub ER stress genes and tumor immune microenvironment and stemness (Supplementary Figure 3, Supplementary Digital Content 5, http://links.lww.com/MD/H132) showed that ZBP1, GNLY, FASLG, TNFRSF21, and CD40LG were positively connected but DIABLO and AURKA were negatively associated with the tumor immune microenvironment; meanwhile, ZBP1, FASLG, TNFRSF21, and CD40LG were negatively associated but DIABLO and AURKA were positively related with tumor stemness. The gene discussed is CD40LG; the disease is neoplasm.