The gene signature consists of 10 necroptosis-related genes (CDKN2A, HAT1, HSP90AA1, IPMK, KLF9, MYCN, NDRG2, PLK1, SQSTM1, and TNFRSF21), most of which are upregulated in HCC tumor tissues and are associated with poor prognosis. Here, SQSTM1 is linked to hepatocellular carcinoma.