The other 38 genes (HDAC9, DDX58, CYLD, MAPK8, CFLAR, MPG, RIPK1, TARDBP, SIRT2, BRAF, BCL2L11, OTULIN, ATRX, DIABLO, STUB1, SPATA2, MLKL, MAP3K7, HAT1, FADD, ITPK1, CASP8, HSP90AA1, RNF31, HSPA4, USP22, TNFRSF21, SLC39A7, TSC1, SQSTM1, TRIM11, TRAF2, DNMT1, LEF1, PLK1, MYCN, CDKN2A, and CDKN2A) were upregulated in HCC samples (Fig. 1B). This evidence concerns the gene OTULIN and hepatocellular carcinoma.