The other 38 genes (HDAC9, DDX58, CYLD, MAPK8, CFLAR, MPG, RIPK1, TARDBP, SIRT2, BRAF, BCL2L11, OTULIN, ATRX, DIABLO, STUB1, SPATA2, MLKL, MAP3K7, HAT1, FADD, ITPK1, CASP8, HSP90AA1, RNF31, HSPA4, USP22, TNFRSF21, SLC39A7, TSC1, SQSTM1, TRIM11, TRAF2, DNMT1, LEF1, PLK1, MYCN, CDKN2A, and CDKN2A) were upregulated in HCC samples (Fig. 1B). The gene discussed is LEF1; the disease is hepatocellular carcinoma.