According to some studies, ANRIL, a lncRNA, is increased in various malignancies, such as lung, liver, stomach, breast, and colon cancer.[3,6,14,16,18] As a new oncogene, it regulates the proliferation, autophagy, metastasis, and other biological behaviors of tumor cells and is involved in the occurrence and development of tumors. This evidence concerns the gene CDKN2B-AS1 and malignant colon neoplasm.