MAP2K7 and osteosarcoma: For example, Guangyang Yu et al reported that high expression of ANRIL connected with the development and prognosis of osteosarcoma and regulated the function of OS cells by the AKT signal pathway.[13] Dongli Zhang et al reported that the PI3K/Akt signal pathway could be inactivated by inhibiting ANRIL in cervical cancer cells.[15] In retinoblastoma Y79 cells and retinal pigment epithelial ARPE-19 cells, high levels of ANRIL expression promoted migration and invasion through activating MEK/ERK and Wnt/β-catenin signal pathway can also downregulate miR-24.[32]