However, studies also report a controversial protumorigenesis effect of AIM2 in selected types of cancer types, like cutaneous squamous carcinoma[53] and nonsmall cell lung cancer.[54] Indeed, AIM2 inflammasome activation can promote the proliferation of cutaneous squamous carcinoma cells by increasing the production of MMP-1 and MMP-13.[53] In parallel, AIM2 leads to the pyroptosis of tumor-associated plasmacytoid dendritic cells with immunosuppressive effects in lung cancer,[55] highlighting the significance of AIM2 in tumorigenesis. This evidence concerns the gene MMP1 and cancer.