HIF1A and neoplasm: It may be related to endo-induced apoptosis of tumor cells, down-regulated expression of VEGF and hypoxic inducible factor (HIF-1α).[38] Recently, Li et al[39] conducted a phase II clinical trial in patients with locally advanced cervical cancer, when VEGFR2 expression was positive, the short-term ORR and DMFS in patients with endostar combined with CCRT were significantly longer than those in patients with CCRT alone (P < .05), and there was no significant increase in treatment-related adverse reactions (P > .05).