VEGFA and neoplasm: Since the needs of rapid tumor cell proliferation surpass the capacity of host vasculature, hypoxia and low supplies of nutrients characterize early stages of tumor development.[8] Hypoxia triggers the expression of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), which promotes tumor angiogenesis.[9] Therefore, targeted communication between tumor cells and adjacent vasculature is the basis of antitumor angiogenesis therapy.