Extensive studies have revealed the important roles of EZH2 in the onset and development of cancer and cell lineage determination during development.[10,31] EZH2 has been found to be closely associated with cancer initiation, progression, metastasis, immune escape, and resistance to treatment.[10,31,32] Being one of the key regulators of the cell cycle, EZH2 mutations and deregulated EZH2 expression lead to acceleration of cell proliferation and retardation of apoptosis, which are related to carcinogenesis. The gene discussed is EZH2; the disease is cancer.