The level of immune dysfunction is related to CD4 cell count, which is usually lower than 100 cells/mm3 at diagnosis.[2] Since the introduction of ART, the survival in this group of patients has significantly improved, with an increase of CD4 cells.[10] In our patient, the initial CD4 cell count was surprisingly higher (216 cell/uL), although CD4 nadir during this period of time was 64 cells/uL. The gene discussed is CD4; the disease is immune system disorder.