Indeed, the p-ERK, p-c-Fos, and p-ELK1 levels were decreased in glioma cells transfected with the miR-3591-3p mimic while transfection of the miR-3591-3p inhibitor led to the opposite trend (Fig. 7A, Supplementary Fig. S7A). This evidence concerns the gene MAPK1 and central nervous system cancer.