It also inhibits the development of T helper 17 cells and enhances T regulatory (T reg) lymphocytes, thus mitigating tissue damage and inflammation.37 Moreover, it suppresses the expression of pro-inflammatory cytokines, specifically interleukin-6 and tumor necrosis factor-α (TNF-α) as both are predictors of severe COVID-19 and worse clinical outcome. The gene discussed is TNF; the disease is COVID-19.