The volcano plot revealed that glial cells in C5 derived from TDL upregulated expression of myelin-related genes (TYMP, CD9, MAG, and PMP22) and immune-related and inflammatory response-associated genes (IL1B and CXCL8) comparing to those from glioma (Fig. 3d; Supplementary Data 3). The gene discussed is TYMP; the disease is central nervous system cancer.