Patients’ temperature and C-reactive protein (CRP), ferritin, and lactic dehydrogenase (LDH) concentrations were elevated, and IL-6 and IFN-γ concentrations were significantly different in grade 3 vs grade 1 CRS (Fig. 1f and Supplementary Fig. 1a–c). The gene discussed is CRP; the disease is congenital rubella syndrome.