CTNNB1 and neoplasm: This immune-exclusion and endothelial anergy state may have been potentiated by immunosuppressive tumor-intrinsic factors (CTNNB1, PTEN, COX11)38,39 in the InflamLOWVascHIGH phenotype, which needs to be studied in context of tumor genetic signatures, mutational burden and immune exclusion40–42.