Male sex became statistically significantly associated with all-cause dementia incidence while age, physical activity (inversely), depression with current pharmacotherapy, and the APOE genotypes ɛ2/ɛ4, ɛ3/ɛ4, and ɛ4/ɛ4 remained significantly associated with all-cause dementia incidence. Here, APOE is linked to major depressive disorder.