This was also the case for the two independent biomarkers for Alzheimer’s disease (EN-RAGE, OR [95% CI]: 1.37 [1.10–1.68], p=0.0048; LAP TGF-beta-1, OR [95% CI]: 1.28 [1.04–1.58], p=0.0187). This evidence concerns the gene TGFB1 and early-onset autosomal dominant Alzheimer disease.