When the two independent biomarkers for all-cause dementia were added simultaneously to the logistic regression models, the OR point estimates per 1 SD increase were attenuated but remained statistically significant (CX3CL1, OR [95% CI]: 1.29 [1.13–1.47], p=0.0002; EN-RAGE, OR [95% CI]: 1.31 [1.15–1.49], p<0.0001). The gene discussed is CX3CL1; the disease is dementia.