For T2D patients with hypertension (Table 4) the TNF-α (β = − 0.297, p = 0.000) and for T2D patients without hypertension (Table 5) OPG had significant contribution to decreased BRS (β = − 0.344, p = 0.004) in the test group. The gene discussed is TNFRSF11B; the disease is hypertensive disorder.