BRCA1 and breast carcinoma: Almost 20% of breast cancer patients share histological features and clinical outcomes with BRCA1/2 related cancers without detectable gBRCA1/2 mutations, a phenotype defined as BRCAness. Beyond gBRCA mutations, somatic BRCA mutation and BRCA silencing through promotor hypermethylation or alterations affecting other genes related to homologous recombination [10] that can mimic the BRCAness state.