When compared with Bowen disease, the proteins expression values of TNC (degree: 1), FSCN1 (degree: 4), SERPINB1 (degree: 0), ACTN1 (degree: 5) and RAB31 (degree: 1) in CSCC were significantly up-regulated, while COL3A1 (degree: 9), COL1A1 (degree: 8), CD36 (degree:0) were significantly down-regulated. The gene discussed is FSCN1; the disease is Bowen disease of the skin.