PMEL and ciliopathy: A report of RPE defects preceding photoreceptor degeneration in a mouse model of BBSome-associated ciliopathy (May-Simera et al., 2018) prompted us to differentiate iPSCs into RPE using a recent protocol (Regent et al., 2020), which is schematically depicted in Figure 2A. RPE cells from control and patient lines were morphologically similar with a characteristic cobblestone appearance (Figure 2B) and expressed typical RPE markers such as PMEL17 (Figure 2B).