Our current results indicated that rCsCP or CsCA might down-regulate the inflammatory responses of colitis mice via elevating Treg cells in both the spleens and MLNs, inducing the release of Th2 cytokines (IL-10, IL-4 and IL-13), and restraining the production of IL-1β and IL-2 cytokines in serum. The gene discussed is IL2; the disease is colitis.