Consistent with previous reports, we also observed Higher levels of LDH in non-survivors compared with survivors (411.3±160.2, and 345.1±131.3, respectively) (Fig 2C), which were also modestly correlated with higher plasma levels of CRP and AAT in all patients (Fig 2D and 2E) and severity of ARDS based on PaO2/FiO2 ratio values (Fig 2F). This evidence concerns the gene SERPINA1 and acute respiratory distress syndrome.