Thus, we can speculate that dietary phosphate loading and high FGF23 condition—even in normophosphatemia—induce hyperphosphaturia, which triggers proximal tubular injury and the initial progression of the eGFR decline without albuminuria and glomerular injury in T1D patients who have susceptibility to renal damage [40]. The gene discussed is FGF23; the disease is type 1 diabetes mellitus.