To further demonstrate that the CD200R1, TOX, and other well-studied genes indeed contribute to T cell exhaustion rather than due to certain diseases and technique factors, we reconducted the WGCNA analysis by removing the T1D dataset (anti-CD3 therapy) (S4 Fig) and confirmed the expressions of corresponding genes in each dataset (S5 Fig). Here, CD200R1 is linked to type 1 diabetes mellitus.