CEP290 and Leber congenital amaurosis: CEP290 c.2991 + 1655A > G is the most commonly found pathogenic variant in this gene, with 60–90% of the individuals with CEP290-related Leber Congenital Amaurosis (LCA) having it in at least one allele (active clinical trials are using CRISPR/Cas9—NCT03872479—and antisense oligonucleotide—NCT03913143—technologies to target this particular variant) (41).