Variants located in these regions were found to be damaging in Tourette’s syndrome (SLITRK1) (49) and Phosphoglycerate kinase 1 deficiency (PGK1) (50); however, these events are certainly rare and supporting evidence regarding their pathogenicity is hard to gather. Here, SLITRK1 is linked to hyperinsulinemic hypoglycemia, familial, 4.