Additionally, soluble factors that are upregulated upon activation of the immune system, such as stromal-derived factor 1 (SDF-1, CXCL12) and CD5L, play a role in immune cell recruitment to sites of lesions and facilitate removal of damage associated molecular patterns (DAMP), both of which play a role in the pathobiology of AD and related dementias. This evidence concerns the gene CXCL12 and dementia.