KLK3 and prostate cancer: In the multivariable adjusted Cox proportional hazards model, treating antidepressant use as time-varying, the biochemical recurrence risk for antidepressant non-use was 34% higher (adjusted HR = 1.34, 95% CI: 1.24–1.44) than for antidepressant use after adjusting for age; stage and year of prostate cancer diagnosis; baseline PSA; Gleason score; race/ethnicity; geocoded median household income; comorbidity status; body mass index; anxiety history; use of anti-anxiety medications; smoking and alcohol misuse; statin and metformin use; and annualized outpatient office visits (Table 4).