According to the results of the study, the best-elected classifiers of ALL status depending on the selected four SNP loci using the cross-validation consistency; training and assessment accuracy were as follows: single locus ROR-γ (rs9017 A/G) followed by FOXP3 (rs3761549C/T) and FOXP3(rs3761548C/A), followed by FOXP3 (rs3761549C/T) and FOXP3(rs3761548C/A) and ROR-γ (rs9017 A/G), followed by the four Sensate three loci consist of SNPs FOXP3 (rs3761549C/T),FOXP3 (rs3761548C/A), and ROR-γ (rs9017 A/G),and the four tested loci seem to be the best classifier cancer status of ALL. The gene discussed is RORC; the disease is acute lymphoblastic leukemia.