Since Treg/Th17 cells play a vital role in cancer, the current study is designated to illuminate the potential genetic link between FOXP3 (rs3761548C/A and rs3761549C/T) and ROR-γ (rs9017A/G & rs9826A/G) SNPs and the occurrence of pediatric ALL in the Egyptian population insights to the clinical disease manifestation. This evidence concerns the gene RORC and acute lymphoblastic leukemia.