The FOXP3 rs3761548CC (OR = 3.07, 95%CI 1.40–6.73, p < 0.01/p < 0.05) and AA (OR = 1.66, 95%CI 0.78–3.52, p > 0.05) genotypes could be associated with an increased ALL risk. This evidence concerns the gene FOXP3 and acute lymphoblastic leukemia.