TGFB1 and acute lymphoblastic leukemia: As previously mentioned by El-maadawy et al. [23], Concerning IL-10 and TGF-β levels (Treg cytokines), ALL patients had a significant decrease (p < 0.001/p < 0.01) in TGF-β level and an increase (p < 0.05/NS) in IL-10 plasma level compared to healthy subjects.