PABPC1 and heart failure: For example, PTMA was shown to drive angiogenesis and improve cardiac function after ischaemic injury in the adult mouse heart and PABPC1 has been implicated in both vascular development and as potentially advantageous in the failing or dilated myocardium.66 Therefore, future interrogation of the effects on endogenous angiogenesis may reveal the relevance of these findings for the treatment of patients with heart failure.