STAT3 and colorectal cancer: 2012; Hu H et al. 2019), and anti-proliferative and pro-apoptotic activities in colorectal cancer (Wu S et al. 2018). STAT3 phosphorylation leads to the transcription of downstream genes that play critical roles in tumorigenesis and inflammation. The expression of myeloid-specific growth factors and inflammatory cytokines responsible for MDSCs differentiation depends on the STAT3 signalling pathway (Kang et al. 2012; Hu M et al. 2015; Ge et al. 2020).