VEGFA and neoplasm: Lymphocytes can recognize tumor cells and have the function of antagonizing tumor activity and preventing tumor cell proliferation and metastasis, while vascular endothelial growth factor (VEGF), matrix metalloproteases released from neutrophils can limit the immune function by inhibiting the killing effect of lymphocytes, resulting in the body in an immunosuppressed state, thus accelerating the proliferation and differentiation of tumor cells.34, 35, 36