Moreover, b‐AP15 induced cleavage of PARP and caspase 3, as well as downregulation of Mcl‐1 and upregulation of Bax (Figure 6D), further supporting the anti‐cancer activities of b‐AP15 in CML. This evidence concerns the gene CASP3 and chronic myelogenous leukemia, BCR-ABL1 positive.