To further verify the activity of b‐AP15 in CML cells and provide research evidence for its clinical application, we explored the biological function of b‐AP15 on PBMCs from BCR‐ABLWT (#1‐#7) and BCR‐ABLMUT (#8 and #9) CML patients. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.