In agreement with these findings, our work revealed that b‐AP15 treatment induced ER stress and cell apoptosis in BCR‐ABLWT and BCR‐ABLT315I CML cells, which may be related to the accumulation of unfolded protein response by inhibiting USP14 and UCHL5. Here, USP14 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.