To test whether USP14 and UCHL5 maintain cell proliferation of CML, we knocked down USP14 and/or UCHL5 in KBM5 and KBM5‐T315I cells and observed that knockdown of either USP14 or USPL5 alone decreased BCR‐ABL expression and CML cell viability (Figure 4A–E). This evidence concerns the gene UCHL5 and chronic myelogenous leukemia, BCR-ABL1 positive.