In a chronic HDM‐induced allergy and Schistosome egg‐induced lung granuloma model, Vannella et al. showed that early combined blockade of IL‐25/IL‐33/TSLP by monoclonal antibody (mAb) treatment can suppresses type 2 cytokine‐driven lung inflammation and fibrosis. This evidence concerns the gene TSLP and Allergy.